The Giant's Run Mountains can be attacked only by flyers or giants. Its defenders are immune to offensive unarmed combat cards.
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TSR
Wizards of the Coast
Due to its restrictions on attackers, this realm is an excellent choice for a realm in the front rank, however, its defensive abilities make it vulnerable to cards like Creeping Doom (402/4th) and Disintegrate (393/2nd).
In defense of the realm, cards that instantly defeat flyers, such as Gloriana (3/1st-chase), Storm Giant (81/FR), and Noble Djinni (84/3rd), work well, as do cards that instantly defeat giants, such as the Sword of Cymrych Hugh (62/FR).
Its defenders are also immune to offensive unarmed combat cards. Coupled with holdings like Hellgate Keep (17/NS), the defenders are now immune to offensive spells and harmful events played while the realm is under attack.
Also, The Mist Caves (14/DR) is a good holding to attach, since it prevents flyers and swimmers from attacking the realm to which it is attached, leaving only giants vulnerable.